Non-Ventilatory Co-Factors of Ventilator-Induced Lung Injury

Numerous experimental studies demonstrate key aspects of mechanical ventilation which initiate or exacerbate acute lung injury, characterized by proteinaceous edema, inflammation, and hemorrhage. The great majority these investigations into Ventilator-Induced Lung Injury (VILI) have focused on the characteristics directly regulated clinician, including individual tidal cycle-tidal volume, inspiratory flow rate, driving Pressure End-Expiratory airway (PEEP).